病理学和细胞病理学教授 (Associate Professor)

美国德克萨斯大学M. D.安德森癌症中心（The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA）

 

1979年至1984 年就读于浙江医科大学 (现浙江大学医学院) 医疗系, 毕业后留校在组胚教研组任教两年。1986年考取该校病理专业徐英含教授的研究生，并于1989年获硕士学位。 1991年前往荷兰, 在Department of Molecular and Developmental Genetics, Catholic University of Nijmegen 从事分子遗传学研究。自1994起, 先后在美国加州大学圣地亚哥分校的医学中心以及The Scripps Research Institute从事蛋白受体与心血管疾病发病机理的研究。1998年至2002年，在芝加哥西北大学(Northwestern University) 接受解剖病理和临床病理住院医训练。继而在美国著名的德克萨斯大学M. D. Anderson癌症中心接受细胞病理学专业培训(Fellowship)。2003年起受聘于该中心。

 

主要研究领域是改良细针穿刺的诊断标准, 提高其诊断的准确率和探索乳腺癌愈后及预测新指标。迄今，已发表学术论文和特邀综述五十余篇，参与编写专著Plasminogen: Structure, Activation and Regulation, Kluwer Academic/Plenum Publishers; Cytology For Oncology;并参与乳腺癌基础研究和临床试验课题二十余项。

 

·   美国细胞病理学协会(American Society of Cytopathology) 的Editorial Review Board七位成员之一

·   全美华人病理学会教育学术委员会（Committee member of the Educational Committee, Chinese American Pathologists Association, CAPA）成员

·   国立癌症研究所(NCI)/国立卫生院(NIH) 科研基金评审委员会成员（study section for RFP SBIR Topic 257）

·   M. D.安得森癌症中心科研基金评审委员会成员

·   为多个病理学及肿瘤学杂志审稿：Modern Pathology; Cancer (Cytopathology); Diagnostic Cytopathology; Histology and Histopathology; Archives of Pathology & Laboratory Medicine; Lancet Oncology; British Journal of Cancer; Gynecologic Oncology; Clinical Biochemistry

·   访问教授：湖北肿瘤医院， 2005 年10月至2008 年10月

 

·   1991-1992年，德国政府科研奖学金 (Deusche Forschungsgemeinshaft）

·   1997 年, Travel Award, American Society of Hematology 39^th Annual Meeting

·   2000年, Award of Alumni Relations and Graduate Medical Education, Northwestern University, Chicago

·   多项获奖乳腺癌科题的重要合作人， 包括两项Susan G.Komen 基金($7.5 millions each)

·   Who’s Who in America, 2009

1.   Parmer RJ, Mahata SK, Jiang Q, Taupenot L, Gong Y, Mahata M, O’Connor DT, Miles LA. Tissue plasminogen activator and chromaffin cell function. Adv Exp Med Biol 482:179-92, 2000.

2.       Parmer RJ, Mahata M, Gong Y, Mahata SK, Jiang Q, O’Connor DT, Xi XP, Miles LA. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. J Clin Invest 106:907-15, 2000.

3.       Gong Y, Kim SO, Grella, DK, Castellino FJ, Miles LA.  Conversion of glu-plasminogen to lys-plasminogen is necessary for optimal stimulation of plasmingen activation on the endothelial cell surface. J Biol Chem 276:19078-83, 2001.

4.       Sun X, Gong Y, Rao S. Loss of CD44s expression is associated with metastatic potential of carcinoid tumor. Mod Pathol 15:1333-38, 2002.

5.       Sun X, Gong Y, Rao S, Badve S. Loss of BRCA1 expression in sporadic male breast carcinoma. Breast Cancer Res Treat 71:1-7, 2002.

6.       Gong Y, Chao J, Bauer B, Sun X, Chou PM. Primary cutaneous alveolar rhabdomyosarcoma of perineum. Arch Pathol Lab Med 126:982-84, 2002.

7.       Zhang L, Gong Y, Grella DK, Castellino FJ, Miles LA. Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface. J Thromb Haemost 1:1264-70, 2003.

8.       Sun X, Gong Y, Pins M. Paratesticular mass in a 55-year-old man. Arch Pathol Lab Med 127:e111-2, 2003.

9.       Gong Y, Sun X, Haines K, Pins M. Renal cell carcinoma, chromophobe type, with collecting duct carcinoma and sarcomatoid components. Arch Pathol Lab Med 127:e38-40, 2003.

10.   Gong Y, DeFrias DV, S, Nayar R.  Pitfalls in fine needle aspiration cytology of extra-adrenal paraganglioma. Acta Cytol 47:1082-6, 2003.

11.   Miles LA, Castellino FJ, Gong Y. Critical role for conversion of glu-glasminogen to lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends Cardiovasc Med 13:21-30, 2003.

12.   Gong Y, Sun X, Attal S, Wiliamson B, Bedrossian CWM. Immunocytochemistry on serous effusion specimens: a comparison of ThinPrep versus cell block. Diagn Cytopathol 28:1-5, 2003.

13.   Gong Y, Caraway N, Gu J, Zaidi T, Fernandez R, Sun X, Katz RL. Evaluation of interface fluorescence in situ hybridization for the t(14;18)(q32;q21) translocation in the diagnosis of follicular lymphoma on fine needle aspirates. Cancer 99:385-93, 2003.

14.   Kidwai N, Gong Y, Sun X, Deshpande CG, Yeldandi A, Rao MS, Badve S. Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. Breast Cancer Res 6:R18-23. 2004.

15.   Gong Y, Symmans FW, Krishnamurthy S, Patel S, Sneige N. Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytology specimens of breast carcinoma. Cancer 102:34-40, 2004.

16.   Sun X, LoAnn P, Gong Y, Traynor AE, Nelson BP. Post-transplant plasma cell myeloma and polymorphic post-transplant lymphoid proliferation with features of Waldenstrom’s macroglobulinemia occurring in solid organ recipients. Mod Pathol 17:389-94, 2004.

17.   Gong Y (corresponding author), Sun X, Huo L, Wiley EL, Rao MS. Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast. Histopathology 46:24-30, 2005.

18.   Gong Y (corresponding author), Jalali M, Staerkel G. Fine needle aspiration cytology of a thyroid metastasis of metaplastic breast carcinoma. Acta Cytol 49:327-30, 2005.

19.   Ren R, Sun X, Staerkel G, Sneige N, Gong Y. (corresponding author) Fine-needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcoma. Diagn Cytopathol 32:38-43, 2005.

20.   Gong Y (corresponding author), Ren R, Ordonez N, Sun X, Sneige N. Fine-needle aspiration cytology of well-differentiated papillary mesothelioma. Acta Cytol 49:537-542, 2005.

21.   Gong Y, Krishnamurthy S. Diagnostic challenge of poorly differentiated   insular carcinoma of the thyroid by fine needle aspiration – one case report. Diagn Cytopathol 32:103-7, 2005.

22.   Gong Y, Booser DJ, Sneige N. Comparison of HER-2 status determined by Fluorescence in Situ Hybridization in primary and metastatic breast cancer. Cancer 103:1763-69, 2005.

23.   Gong Y (corresponding author), Sun X. Fine-needle aspiration of a presacral myelolipoma. Diagn Cytopathol 34:29-30, 2006.

24.   Gong Y (corresponding author), Joseph T, Sneige N. Validation of commonly used immunostains on cell-transferred cytologic specimens. Cancer105:158-64, 2005.

25.   Gong Y, Gilcrease M, Sneige N. Chromogenic in situ hybridization (CISH) in the evaluation of HER-2 status – interobserver reproducibility and comparison with fluorescence in situ hybridization (FISH). Mod Pathol 18:1015-21, 2005.

26.   Anderson K, Hess KR, Kapoor M, Tirrell S, Courtemanche J, Wang B, Wu Y, Gong Y, Hortobagyi GN, Symmans WF,  Pusztai L. Reproducibility of gene expression signature based predictions in replicate experiments. Clin Cancer Res 12:1721-27, 2006.

27.   Gong Y (corresponding author), Sneige N., Guo M, Hicks M, Moran C. Transthoracic fine needle aspiration versus concurrent core needle biopsy in diagnosis of intrthoracic lesions: a retrospective comparison of diagnostic accuracy. Am J Clin Pathol 125:438-44, 2006.

28.   Gong Y (corresponding author), Joseph T, Sneige N. Author reply to immunohistochemistry performed on cell-transferred cytologic specimens. Cancer 108:135-136, 2006.

29.   Alrahwan D, Staerkel G, Gong Y. (corresponding author) Fine needle aspiration cytology of a metastatic ductal adenocarcinoma of the prostate. Acta Cytol 50:469-72, 2006.

30.   Huang P, Sneige N, Staerkel G, Gong Y. (corresponding author) Fine-Needle aspiration of pancreatic serous cystadenoma: cytologic features and diagnostic pitfalls. Cancer 108:239-49, 2006.

31.   Sneige N, Liu B, Yin G, Gong Y, Arun B. Correlation of cyologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer. Mod Pathol 19:622-629, 2006.

32.   Gong Y (corresponding author), Caraway N, Stewart J, Staerkel G. Metastatic ductal adenocarcinoma of the prostate: cytologic features and clinical findings. Am J Clin Pathol 126:302-9, 2006.

33.   Ren R, Guo M, Sneige N, Moran C, Gong Y. (corresponding author) Fine-needle aspiration of adrenal cortical carcinoma: cytologic spectrum and diagnostic challenges. Am J Clin Pathol 126:389-398, 2006.

34.   Ganzalez-Angulo, A, Guarneri, V, Gong, Y, Cristofanilli, M, Morales-Vasquez, F, Sneige, N, Hortobagyi, G, Esteva, F. Downregulation of the cyclin-dependant kinase inhibitor p27^kip1 might correlate with poor disease-free and overall survival in inflammatory breast cancer. Clin Breast Cancer 7:326-30, 2006.

35.   Cabioglu N, Gong Y (co-first author), Broglio K, Islam R, Sneige N, Sahin A., Gonzalez-Angulo AM, Marandi P, Bucana C, Hortobagyi G, Cristofanilli M. Expression of growth factors and chemokine receptors: New insights in the biology of inflammatory breast cancer. Ann Oncol 18:1021-9, 2007.

36.   Gong Y (corresponding author), Yan K, Lin F, Anderson K, Sotiriou C, Andre F, Holmes FA, Valero V, Booser D, Pippen JE, Vukelja, S, Gomez H, Mejia J, Barajas LJ, Hess KR, Sneige N, Hortobagyi GN, Pusztai L, Symmans, WF.  Determination of estrogen receptor and HER-2 status of breast carcinoma using mRNA measurements from Affymetrix gene expression profiling. Lancet Oncol 8:203-11, 2007.

37.   Arun B, Logan C, Broglio K, Yin C, Valero V, Kuerer H, Meric-Bernstam F, Gong Y, Browne D, Hortobagyi GN, Sneige N. Comparison of ductal lavage and random periaroelar fine-needle aspiration as tissue acquisition methods in early breast cancer prevention trials. Clin Cancer Res 13:4943-48, 2007.

38.   Gong Y (corresponding author), Symmans, WF, Pusztai, L. Gene expression microarrays provide new prognostic and predictive tests for breast cancer (Review). Pharmacogenomics 8: 1359-1368, 2007.

39.   Dawood S, Broglio K, Gong Y, Yang, WT, Cristofanilli, M, Kau SW, Meric FB, Buchholz TA, Hortobaghy GN, Ganzalez-Angulo A. Prognostic significance of HER2 status in women with inflammatory breast cancer. Cancer 112:1905-1911, 2008.

40.   Piao Y, Guo M, Gong Y (corresponding author). Fine-needle aspiration cytology of metastatic spindle cell melanoma: a study of 81 cases. Cancer 114:94-101, 2008.

41.   Guo, M, Gong Y. Evaluation of a commercialized in situ hybridization assay for detecting human papillomavirus DNA in cervical intraepithelial neoplasia and cervical carcinoma. J Clin Microbiology 46:274-80, 2008

42.   Guo M, Lin CY, Gong Y, Cogdell DF, Zhang W, Lin E, Sneige N. Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results. Mod Pathol. 21:1037-43, 2008.

43.   Gong Y (corresponding author). Pathology aspect of inflammatory breast cancer: Biologic insights of its aggressive phenotype (Review). Semin Oncol, 35;33-40, 2008.

44.   Uzquiano MC, Prieto, VG, Nash, JW, Ivan, DS, Gong Y, Lazar AJ, Diwan AH.  Metastatic basal cell carcinoma. Mod  Pathol, 21:540-43, 2008.

45.   Angeles R, Gong Y (corresponding author) Fine needle aspiration of a subcutaneous gouty tophus. Diagn Cytopathol, 36:494-95, 2008.

46.   Payne M, Staerkel G and Gong Y (corresponding author) Indeterminate diagnosis in fine-needle aspiration of the pancreas: reasons and clinical implications. Diagn Cytopthol 37:21-9, 2009

47.   Gong Y (corresponding author), Sweet W, Duh YJ, Greenfield L, Fang Y, Zhao J, Tarco E, Symmans WF, Isola J, Sneige. Chromogenic in situ hybridization (CISH) is a reliable method for detecting HER2 gene status in breast cancer: A multicenter study using conventional scoring criteria and the new ASCO/CAP recommendations. Am J Clin Pathol 131: 490-97, 2009.

48. Ge Y, Sneige N, Eltorky MA, Wang Z, Lin E, Gong Y, Guo M Immunohistochemical characterization of subtypes of male breast carcinoma Breast Cancer Res. 2009 May 14;11(3):R28.

49. Gong Y (corresponding author), Sweet W, Duh YJ, Greenfield L, Trivedi S, Symmans WF, Isola J, Sneige N. Performance of chromogenic in situ hybridization on testing HER2 status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) HercepTest: a study of two institutions using conventional and the new ASCO/CAP scoring criteria. Am J Clin Pathol 132: 228-36, 2009.

50. Pusztai L, Jeong J, Gong Y, Ross J, Kim C, Hortobagyi GN, Paik S, Symmans, WF, Evaluation of microtubule associated protein Tau expression as prognostic and predictive maker in the NSABP-B 28 randomized clinical trial. Accepted and In Press 3.2009 Journal of Clinical Oncology